Investigation of bubble dynamics in ultrasonic sonoporation

Abstract

During the process of quickly producing pathologic sections of the living tissues with ultrasonic sonoporation, it has been found that the exciting ultrasonic signal has an evident effect on the pathologic section. For the sake of understanding the effect and obtaining the best state of quickly producing pathologic section, the bubble dynamics in ultrasonic sonoporation is investigated by constructing a model of cavitated bubbles and altering the parameters, such as the ultrasonic signal frequency, acoustic pressure, bubbles' original radius and viscosity of the fluid. Numerical simulations indicate that radial vibration of cavitating bubble can keep on a steady process of expanding, shrinking, and vibrating in a given rang of frequencies, and one can find out the best original radius for obtaining the maximal cavitation. There exist a best cavitation regions which are determined by the parameters, i.e., the ultrasonic signal frequency, acoustic pressure, bubbles' original radius and viscosity of body fluid.