Affiliation:
1. VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, VETERİNER PR.
2. MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, FETHİYE SAĞLIK BİLİMLERİ FAKÜLTESİ
3. VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ
Abstract
Diabetes mellitus (DM) is a chronic metabolic non-commu¬nicable disease; it is globally considered the fifth cause of death and it has attained worldwide epidemic pro¬portions. In our study, we aimed to investigate the diabetic effects of Solanum nigrum extract using the control group (C), diabetes group (D), groups given the Solanum nigrum extract (SN) and diabetes group + Solanum nigrum extract (D+SN). Our results observed the biological effectiveness of Solanum nigrum extract on glucose levels, significant increase serum glucose level group (D) (663±21.8 mg/dL) in comparison with C (131±9.8 mg/dL) were recorded. However, there were no significant difference in glucose level between C group (131±9.8 mg/dl) and SN group (196.14±12.1 mg/dL). Moreover, glucose level of D+SN group (484.8±40.0 mg/dL) was significantly higher than C (131±9.8 mg/dl), D (663±21.8 mg/dl) and SN groups (196.14±12.1 mg/dL). Total antioxidant status (TAS) level in D group (1.85±0.15.7) was significant when compared C group (1.28±0.17). Significant differences were observed between D group and D+SN group (1.54±0.07). However, TAS levels showed no significant difference in both SN (1.27±0.10) and D+SN (1.54±0.07) groups in comparison to the control group. Total oxidant status (TOS) level in D group (6.30±1.41) was given significant differences in comparison with control C (3.87±0.34), SN (4.87±0.80) group and D+SN (4.14±0.34) groups. In contrary, there were no significant differences between all of C, SN, D+SN groups. As a result, we can say that the Solanum nigrum plant extract is effective on diabetes, but it cannot lower the glucose level to normal levels, it needs to be investigated in future studies and its effects at different doses by different extraction methods.
Subject
General Chemical Engineering
Reference32 articles.
1. Aali NS, Singh K, Khan M, Rani S (2010). Protective Effect of Ethanolic Extract of Solanum Nigrum on the Blood Sugar of Albino Rats. Int J Pharma Sci and Res,1 (9), 97-99.
2. Adebooye OC, Vijayalakshmi R, Singh V (2008). Peroxidase Activity, Chlorophylls and Antioxidant Profile of Two Leaf Vegetables (Solanum Nigrum L. and Amaranthus Cruentus L.) Under Six Pretreatment Methods Before Cooking. Int J Food Sci and Techno, 43, 173-178.
3. Ahmet AK, Mert H, Nihat M (2019). Investigation of the Antidiabetic Effects of Mistletoe (Viscum album L.) Extract in Experimental Diabetes in Rats. Van Vet J, 30 (2), 121-125.
4. Alam A, Sahar A, Sameen A, Faısal MN (2022). The effects of bioactive components in Solanum nigrum against oxidative stress in liver damage. Food Sci Technol, 42, e61822.
5. Al-kuraishy HM, Al-Gareeb AI, Alblihed M et al. (2021). COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus. Front Cardiovasc Med, 8, 1-13.