INFLUENCE OF VASCULAR STENT SURFACE TREATMENT WITH AN ADAPTIVE COMPOSITION (AdC) FOR IMPROVING ITS BIOCOMPATIBILITY AND RESTENOSIS PREVENTION (experimental research)

Abstract

Introduction. The article describes a method of implant surface treatment that reduces the risk of an inflammatory reaction to vascular implants. The aim of the research was to develop a method of coating the surface of vascular implants (stents) to reduce the risk of inflammation reaction (rejection), enhance their biocompatibility, and prevent restenosis. Materials and methods. The research was conducted on 34 male rabbits of the "Flemish Giant" breed weighing 2.5-3.0 kg, following the standards of bioethical principles. The blood vessels of the experimental animals were previously provoked by the administration of endogenous pyrogenic solution according to a predetermined protocol. Under general anesthesia, the animals were endovascularly (via femoral access into the abdominal aorta) implanted with standard Z-shaped stents made of 316L stainless steel. To obtain indicative results, 10 rabbits were implanted with non-treated stents, while another 12 rabbits had stents pre-treated with the adapting composition (AdC) implanted. After 8 weeks, the animals were withdrawn from the experiment. Results and discussion. Vessel wall morphometry revealed that the treatment of stents with AdC before their placement into the vessel resulted in a reduction of vessel wall thickness at the site of their implantation. Conclusions. The developed method involves pre-treatment of stents with AdC , which in turn ensures a reduction in the reaction of the surrounding tissues thanks to the modification of the implant surface, reduces the thickness of neointima growth, which indicates the absence of inflammatory processes and the formation of fibrous tissue around the implant. The clinical application of AdC aimed at improving the biocompatibility properties of implants with respect to the recipient's body is characterized by a 100% (95% CI 78.2% - 100%) likelihood of absence of complications.