Gastric Retentive Drug Delivery system and its recent insights : A Review

Abstract

Oral route is believed to be the most convenient and profoundly accepted drug delivery system and to enhance the efficiency of oral delivery of drug and to overcome the physicochemical and biological barriers in oral delivery, concept of novel delivery system is introduced.Gastro retentive drug delivery system (GRDDS) is one such type of drug delivery system. In conventional delivery system it is hard to provide drug at specific site, but on other hand GRDDS we can retain the drug in stomach for prolong period. There is various approach for retention of drug in stomach like high density, low density (floating system), magnetic, raft forming, bio-adhesive systems, which helps increase the bio-availability of drug. Drugs with good acid solubility, instability at alkaline pH, narrow absorption window, can be formulated by this system. This review includes introduction, potentialcandidates, advantages, disadvantages, approaches, formulation aspects, marketed preparations, current insights including ongoing research and patent works. This review article will help researchers and medical students to have better understanding on GRDDS which ultimately help themin formulation and designing of GRDDS.