Associations of Accelerometer-Measured Physical Activity and Sedentary Time With All-Cause Mortality by Genetic Predisposition for Longevity-Reference-Cited by-全球学者库

Associations of Accelerometer-Measured Physical Activity and Sedentary Time With All-Cause Mortality by Genetic Predisposition for Longevity

Published:2023-04-01 Issue:2 Volume:31 Page:265-275
ISSN:1063-8652
Container-title:Journal of Aging and Physical Activity
language:
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Author:

Posis Alexander Ivan B.¹²^ORCID,Bellettiere John¹,Salem Rany M.¹,LaMonte Michael J.³,Manson JoAnn E.⁴⁵,Casanova Ramon⁶,LaCroix Andrea Z.¹,Shadyab Aladdin H.¹

Affiliation:

1. Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA

2. School of Public Health, San Diego State University, San Diego, CA, USA

3. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY, USA

4. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

5. Harvard Medical School, Boston, MA, USA

6. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA

Abstract

The goal of this study was to examine associations between accelerometer-measured physical activity (PA) and sedentary time (ST) with mortality by a genetic risk score (GRS) for longevity. Among 5,446 women, (mean [SD]: age, 78.2 [6.6] years), 1,022 deaths were observed during 33,350 person-years of follow-up. Using multivariable Cox proportional hazards models, higher light PA and moderate to vigorous PA were associated with lower mortality across all GRS for longevity categories (low/medium/high; all ptrend < .001). Higher ST was associated with higher mortality (ptrend across all GRS categories < .001). Interaction tests for PA and ST with the GRS were not statistically significant. Findings support the importance of higher PA and lower ST for reducing mortality risk in older women, regardless of genetic predisposition for longevity.

Publisher

Human Kinetics

Subject

Geriatrics and Gerontology,Gerontology,Rehabilitation,Physical Therapy, Sports Therapy and Rehabilitation

Link

https://journals.humankinetics.com/downloadpdf/journals/japa/31/2/article-p265.xml

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