Pathogenetic features of post-burn skin scarring: modern methods of early treatment and prevention (review)

Author:

Komkov Konstantin N.1ORCID,Chmyrev Igor V.1ORCID,Kozyaev Vasiliy A.1ORCID

Affiliation:

1. S.M. Kirov Military Medical Academy

Abstract

Objective: to analyze the effectiveness of modern methods of prevention and early treatment of scarring in burned patients, taking into account pathogenetic mechanisms. The methodology of writing a review. The review was performed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology using the eLibrary, PubMed, and Medline databases. The search depth is from 2003 to 2024. Number of sources viewed —1372. The review includes 16 original studies. The most effective and widely used methods of early treatment and prevention of scars in burned patients have been established. Conclusion. The analysis of scientific papers revealed that early excision of granulation tissue and fibrously altered dermis, followed by autodermoplasty with full-layer skin grafts, as well as the complex use of drugs whose mechanism of action is aimed at suppressing the metabolic activity of fibroblasts (glucocorticosteroids, calcium channel blockers), worsening blood supply in the scar, removing excess extracellular matrix, reducing moisture loss from the skin surface, improves the characteristics of the emerging scar tissue.

Publisher

LLC Science and Innovations

Reference24 articles.

1. Alekseyev АА, Bobrovnikov АЕ, Malyutina NB, et al. Analysis and features of the work of burn hospitals in Russia in 2022. In: Burns: Diagnosis, treatment, rehabilitation Abstracts of the All-Russian scientific and practical conference. Makhachkala, 2023.

2. Sokolov VA, Efimenko NA, Admakin AL. Peacetime burns. Sources of danger. Clinical Medicine. 2015; (6):30-5.

3. Grechishnikov Ml. Algorithm of surgical treatment of patients with the consequences of burn injury. PhD diss. Moscow, 2015; 109 p.

4. Filippova OV, Afonichev КА, Krasnogorskiy IN, et al. Clinical and morphological features of the vascular bed of hy-pertrophic scar tissue at different periods of its formation. Orthopedics, Traumatology and Reconstructive Surgery for Children. 2017;5 (3):25-36.

5. Plomgaard AM, Alderliesten Т, Austin Т, et al. Early biomarkers of brain injury and cerebral hypo- and hyperoxia in the SafeBoos С II trial. PLoS One. 2017;12 (3):e0173440. DOM 0.1371/journal, pone.0173440

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