Herbicide residues as a possible risk factor in semen quality and spermatogenesis

Abstract

Background Reports from various countries have consistently demonstrated a correlation between herbicide exposure, arising from agricultural practices, and a decline in semen quality, leading to male infertility. This study was conducted at Ekiti State University Teaching Hospital in Ado-Ekiti, a rural community characterized by a predominantly agrarian population to determine the relationship between semen quality and herbicides residues. Methods The study focused on males whose spouses were seeking assistance at infertility clinics. Routine semen analyses were performed according to the World Health Organization (WHO) criteria, categorizing samples into normospermic, asthenospermic, oligospermic, and azoospermic groups. Seminal plasma samples from each group (twenty samples per group) were subjected to analysis for the presence and concentration of herbicides using High-Performance Liquid Chromatography (HPLC). The following herbicides were investigated: halosulfurum, linuron, fluometuron, chlo-rimuron, imaxamox, cloransulam, dicamba, fluroxypor, trichlopyr, propanil, cloclinafop, clethodim, quizalofop, fluazifop, pinoxaden, bentazon, atrazine, and bromoxynil. The obtained results were subjected to statistical analysis using SPSS version 24. Results The analysis revealed significantly higher concentrations of most herbicides in the asthenospermia, oligospermia, and azoospermia groups compared to the normospermic group (P<0.05). These findings suggest a strong association between herbicide exposure and poor semen quality in the studied population.Conclusion This study provides compelling evidence supporting the hypothesis that herbicides exposure could be a contributory factor to diminished semen quality in the investigated rural com-munity. The results underscore the importance of considering seminal herbicide determination as a routine component in male infertility testing. Additionally, the study advocates for the implementation of relevant legislation to mitigate potential risks associated with herbicide exposure.