Author:
Uddin Shaikh Jamal,Ahnaf Tasfiya Rufaidah,Sarkar Pritam,Shikdar Md. Emam,Saha Sudipto
Abstract
Among various plants in the Mangrove Forest of the tropical and subtropical region, E. agallocha is notable for possessing multifarious pharmacological activity. As E. agallocha belongs to the Euphoriaceae family, this plant is rich in many classes of phytochemicals that are therapeutically potent such as Diterpenoids, Triterpenoids, Alkaloids, Polyphenol, Sterol, Flavonoids, Tanine, Flavanone, etc. Its ancient use in the treatment of disorders such as epilepsy, rheumatism, ulcer, leprosy, and others has attracted the interest of researchers, who are now studying different parts of the plant. Plant parts have been studied for reducing inflammation, anti-microbial, anti-epileptic, and cytotoxic effects in several research. Phytoconstituents responsible for pharmacological activities have been distinguished and their possible mechanism of action along with IC₅₀ value has been presented. From wood, roots, and stems of the plant physiologically active constituents such as Agallochin, ent-kauran-16â-ol-3-one, Chebulagic acid, Betulinic acid, Betulonic acid, Corilagin, Geraniin, Excoecarin, Agallochaexcoerin, Vanillic acid are described as pharmacologically potent molecules as they interact with certain biomolecules and precipitate changes in the physiological state of the body. This review is elucidating the likely mechanism of action of each of these plant compounds that provide particular biological activity.