Affiliation:
1. West China School of Medicine
2. Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Abstract
Objective
Botulinum toxin (Btx) therapy has emerged as a potential treatment for patients with Raynaud phenomenon (RP) in recent years. This study aimed to investigate the efficacy and safety of Btx treatment for RP.
Methods
Databases of PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched from their inception up to August 2022. Studies that reported Btx use for the treatment of RP were included. A meta-analysis was conducted for the Shortened version of the Disabilities of the Arm, Shoulder, and Hand (Quick DASH) score and visual analog scale pain score using a random-effects model.
Results
Thirteen full-text studies were included. The pooled standard mean changes for the visual analog scale pain score and QuickDASH score were −3.82 (95% confidence interval, −6.62 to −1.02) and 0.83 (95% confidence interval, −1.47 to −0.19), respectively. The 2 most common complications were injection site pain and intrinsic hand weakness.
Conclusions
The effect of Btx treatment on RP is promising based on current evidence. Nevertheless, more studies and randomized clinical trials with larger sample sizes are needed to confirm the current results.
Publisher
Ovid Technologies (Wolters Kluwer Health)