Reviewing the dysregulation of ADAMTS13 and VWF in sepsis

Abstract

Abstract Sepsis is defined as a life-threatening organ dysfunction caused by excessive host response to infection, and represents the most common cause of in-hospital deaths. Sepsis accounts for 30% of all critically ill patients in the Intensive Care Unit (ICU), and has a global mortality rate of 20%. Activation of blood coagulation during sepsis and septic shock can lead to disseminated intravascular coagulation (DIC) which is characterized by microvascular thrombosis. Von Willebrand Factor and ADAMTS13 are two important regulators of blood coagulation that may be important links between sepsis and mortality in the ICU. Herein we review our current understanding of Von Willebrand Factor and ADAMTS13 in sepsis and other critical illnesses and discuss their contribution to disease pathophysiology, their utility as markers of severe illness, and potential targets for new therapeutic development.