Teprotumumab-related Cutaneous Hypersensitivity Reactions

Author:

Dallalzadeh Liane O.1ORCID,Ting Michelle1,Topilow Nicole1,Robbins Shira L.2,Liu Catherine Y.1,Burkat Cat N.3,Korn Bobby S.14,Kikkawa Don O.14

Affiliation:

1. Division of Oculofacial Plastic and Reconstructive Surgery, Viterbi Family Department of Ophthalmology, Shiley Eye Institute, UC San Diego, La Jolla, CA, U.S.A.

2. Division of Pediatric Ophthalmology and Adult Strabismus, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, U.S.A.

3. Division of Ophthalmic Facial Plastic Surgery, Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI, U.S.A.

4. Division of Plastic and Reconstructive Surgery, Department of Surgery, UC San Diego, La Jolla, CA, U.S.A.

Abstract

The authors report 4 cases of cutaneous hypersensitivity reactions developing in the course of teprotumumab treatment for thyroid eye disease. The onset of the cutaneous hypersensitivity reaction was also observed during the treatment course in all cases, between the second and fifth infusions. Teprotumumab-related cutaneous reactions suggest a possible immunogenic component of the monoclonal antibody and highlight the importance of close monitoring during treatment.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Ophthalmology,General Medicine,Surgery

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