Abstract
Background
The present study aims to explore the relationship between perfluoroalkyl substances (PFAS) exposure and hyperlipidemia using data from the National Health and Nutrition Examination Survey.
Methods
A total of 1600 subjects were included in the analysis, and nine kinds of PFAS were measured. Multivariate logistic regression analysis was performed to explore the association between serum PFAS and hyperlipidemia.
Results
Compared with the lowest quartile of perfluoromethylheptane sulfonic acid isomers (Sm-PFOS), the percentage change for hyperlipidemia was 57% and 41% in the third and highest quartile of PFOS. The positive association between Sm-PFOS and hyperlipidemia remained significant in population younger than 60 years, and the odds ratio for hyperlipidemia in fourth quartile of Sm-PFOS was 1.81.
Conclusions
These findings indicated that serum Sm-PFOS was independently associated with a higher risk for hyperlipidemia. The epidemiological study warrants further study to elucidate the causal relationship between them.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Public Health, Environmental and Occupational Health
Reference41 articles.
1. The forgotten lipids: triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk;Endocr Rev,2019
2. Heart Disease and Stroke Statistics-2021 update: a report from the American Heart Association;Circulation,2021
3. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines;Circulation,2019
4. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk;Eur Heart J,2020
5. Clinical management of hypertriglyceridemia in the prevention of cardiovascular disease and pancreatitis;Curr Atheroscler Rep,2021