Characteristics of bone metabolism in the male patients with diabetic neuropathy

Abstract

Background: This study aimed to evaluate the characteristics of bone metabolism and fracture risk in the type 2 diabetes mellitus (T2DM) patients with distal symmetric polyneuropathy (DSPN). Methods: A total of 198 T2DM individuals were recruited from January 2017 to December 2020. Patients with DSPN were evaluated by strict clinical and sensory thresholds. Biochemical parameters and bone mineral density (BMD) were measured. The BMD, bone turnover markers and probability of fracture were compared between two groups, and the factors related to BMD and probability of hip fracture in 10 years were further explored. Results: Compared with T2DN- patients, T2DN+ patients had lower level of cross-linked C-telopeptide (CTX) (0.32 ±0.19 vs 0.38±0.21ng/mL, p =0.0378) and higher level of bone specific alkaline phosphatase (BALP) (15.28±5.56 vs 12.58±4.41μg/mL, p =0.0025). T2DN+ patients had higher BMD of lumbar 1-4 (1.05±0.19 vs 0.95±0.37, p =0.0273) and higher probability of hip fracture (0.98±0.88 vs 0.68±0.63, p =0.0092) as compared to T2DN- individuals. Univariate correlation analysis showed that BALP level (coef=-0.054, p =0.038), CTX level (coef=-2.28, p =0.001) and hip fracture risk (coef=-1.02, P<0.001) were negatively related to the BMD of L1-4. As for the risk of hip fracture evaluated by FRAX, age (coef=0.035, p <0.001), use of insulin (coef=0.31, p =0.015) and levels of BALP (coef=0.031, p =0.017) and CTX (coef=0.7, p =0.047) were positively related to the risk of hip fracture. Multivariate regression analysis showed that CTX level (coef=-1.41, p =0.043) was still negatively related to BMD at the lumbar spine. Conclusion: This study indicates that T2DM patients with DSPN have special bone metabolism represented by higher BALP level and lower CTX level which may increase BMD at the lumbar spine.