Structure-based approaches against COVID-19-Reference-Cited by-全球学者库

Structure-based approaches against COVID-19

Published:2023-12-20 Issue:2 Volume:87 Page:139-141
ISSN:1726-4901
Container-title:Journal of the Chinese Medical Association
language:en
Short-container-title:

Author:

Huang Ta-Chou¹²,Liang Kung-Hao¹³⁴,Chang Tai-Jay¹⁵⁶,Hung Kai-Feng¹,Wang Mong-Lien¹³,Cheng Yen-Fu¹,Liao Yi-Ting¹,Yang De-Ming¹²

Affiliation:

1. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC

2. Institute of Biophotonics, School of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC

3. Institute of Food Safety and Health Risk Assessment, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC

4. Institute of Biomedical Informatics, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC

5. Laboratory of Genome Research, Basic Research Division, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC

6. School of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has had a major impact on human life. This review highlights the versatile roles of both classical and modern structure-based approaches for COVID-19. X-ray crystallography, nuclear magnetic resonance spectroscopy, and cryogenic electron microscopy are the three cornerstones of classical structural biology. These technologies have helped provide fundamental and detailed knowledge regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the related human host proteins as well as enabled the identification of its target sites, facilitating the cessation of its transmission. Further progress into protein structure modeling was made using modern structure-based approaches derived from homology modeling and integrated with artificial intelligence (AI), facilitating advanced computational simulation tools to actively guide the design of new vaccines and the development of anti-SARS-CoV-2 drugs. This review presents the practical contributions and future directions of structure-based approaches for COVID-19.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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