Research on the genetic etiology of polycystic ovary syndrome in the post-GWAS era-Reference-Cited by-同舟云学术

Research on the genetic etiology of polycystic ovary syndrome in the post-GWAS era

Published:2024-06-26 Issue:3 Volume:9 Page:
ISSN:2473-3709
Container-title:Global Reproductive Health
language:en
Short-container-title:

Author:

Zhao Shigang¹²³,Zhao Han¹²³,Chen Zi-Jiang¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China

2. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China

3. Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China

4. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

5. Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Abstract

Great progress has been made in the genetic research of PCOS, thanks to the application of genome association study (GWAS) technology. However, in the post-GWAS era, investigating the pathogenic mechanisms related to numerous genetic loci has become challenging, leading to the current generalized approach to treating PCOS. To address this issue, taking the significantly associated susceptibility gene THADA as an example, we share a series of advancements from the perspectives of genetic evolution, epigenetics, and gene function studies. Our aim is to provide guidance for a better understanding of the essence of PCOS.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference5 articles.

1. Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification;Dapas;Endocr Rev,2022

2. THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass;Zhang;Nat Commun,2023

3. Thada is dispensable for female fertility in mice;Han;Front Endocrinol,2022

4. Evidence of positive selection of genetic variants associated with PCOS;Yu;Hum Reprod,2023

5. Deciphering the DNA methylome in women with PCOS diagnosed using the new international evidence-based guidelines;Wang;Hum Reprod,2023