Author:
Blakley Brian W.,Cohen James I.,Doolittle Nancy D.,Muldoon Leslie L.,Campbell K. C.,Dickey D. Thomas,Neuwelt Edward A.
Abstract
AbstractObjectives To summarize the findings relevant to otolaryngology from the annual meeting of the Blood–Brain Barrier Disruption Consortium in Gleneden Beach, Oregon, March 10, 2001.Study Design Summaries are provided by the speakers, as well as related data from the published literature. Findings in otology and oncology regarding ototoxicity that were discussed at the meeting are included.Results Data considered included physiological research, animal studies, and clinical trials that relate to platinum‐based chemotherapy and prevention of toxicity.Conclusions The dose‐limiting side effects of platinum‐based chemotherapy are preventable, but questions about the effect of the protective agents on oncological efficacy remain. Strategies for prevention of chemotherapy‐induced toxicity include temporal or anatomical separation of cisplatin or carboplatin from sodium thiosulfate, D‐methionine, or N‐acetyl‐cysteine. Clinical application of these methods has begun. The mechanisms presumably involve free radicals or drug conjugation, or both. Understanding the role of free radicals in medicine is likely to become important in the future.
Reference45 articles.
1. Therapeutic efficacy of aortic administration of N‐acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in rat model;Neuwelt EA;Cancer Res,2001
2. A review of cis‐platinum ototoxicity;Moroso MJ;J Otolaryngol,1983
3. Cisplatin Metabolites and their Toxicity on Isolated Cochlear Outer Hair Cells in Vitro
4. Cisplatin blocks voltage-dependent calcium current in dissociated outer hair cells of guinea-pig cochlea
5. Cisplatin-induced ototoxicity: Audiometric findings and experimental cochlear pathology
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