Provocative findings from a transdiagnostic counseling intervention to improve psychiatric comorbidity and HIV care engagement among people with HIV: A Pilot Randomized Clinical Trial

Author:

Pence Brian W.1,Darnell Doyanne2,Ranna-Stewart Minu3,Psaros Christine4,Gaynes Bradley N.15,Grimes LaKendra6,Henderson Savannah6,Parman Mariel6,Filipowicz Teresa R.1,Gaddis Kathy6,Dorsey Shannon7,Mugavero Michael J.6

Affiliation:

1. Department of Epidemiology, the University of North Carolina at Chapel Hill

2. Department of Psychiatry and Behavioral Sciences, the University of Washington

3. University of Washington

4. Department of Psychiatry, Harvard Medical School

5. Department of Psychiatry, the University of North Carolina at Chapel Hill

6. Division of Infectious Diseases, the University of Alabama at Birmingham

7. Department of Global Health, the University of Washington

Abstract

Background: Depression, anxiety, post-traumatic stress (PTS), and alcohol/substance use disorders are prevalent among people with HIV (PWH), commonly co-occur, and predict worse HIV care outcomes. Transdiagnostic counseling approaches simultaneously address multiple co-occurring mental health disorders. Methods: We conducted a pilot individually randomized trial of the Common Elements Treatment Approach adapted for people with HIV (CETA-PWH), a transdiagnostic counseling intervention, compared to usual care at a large academic medical center in the southern US. Participants were adults with HIV, at risk for HIV care disengagement, with elevated symptoms of depression, anxiety, PTS, and/or alcohol/substance use. Mental health and HIV care engagement were assessed at four and nine months. Results: Among participants (n=60), follow-up was high at four (92%) and nine (85%) months. Intervention engagement was challenging: 93% attended ≥1 session, 43% attended ≥6 sessions in three months (“moderate dose”), and 30% completed treatment. While not powered for effectiveness, mental health outcomes and HIV appointment attendance improved in CETA-PWH relative to usual care in intent-to-treat analyses; those receiving a moderate dose and completers showed progressively greater improvement. Viral load showed small differences between arms. The dose-response pattern was not explained by differences between those who did and did not complete treatment. Conclusions: This pilot trial provides preliminary evidence for the potential of CETA-PWH to simultaneously address co-occurring mental health co-morbidities and support HIV appointment attendance among PWH. Additional strategies may be an important part of ensuring that clients can engage in the full course of treatment and realize its full benefits.

Funder

NIMH

NIAID

Publisher

Ovid Technologies (Wolters Kluwer Health)

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