Lipid droplet deposition in the regenerating liver: A promoter, inhibitor, or bystander?

Author:

Hu Yuelei1ORCID,Wang Ruilin2ORCID,Liu Juan3456ORCID,Wang Yunfang3456ORCID,Dong Jiahong1345

Affiliation:

1. Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Jilin University, Changchun, China

2. Department of Cadre’s Wards Ultrasound Diagnostics. Ultrasound Diagnostic Center, The First Hospital of Jilin University, Jilin University, Changchun, China

3. Research Unit of Precision Hepatobiliary Surgery Paradigm, Chinese Academy of Medical Sciences, Beijing, China

4. Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China

5. Institute for Organ Transplant and Bionic Medicine, Tsinghua University, Beijing, China

6. Clinical Translational Science Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China

Abstract

Liver regeneration (LR) is a complex process involving intricate networks of cellular connections, cytokines, and growth factors. During the early stages of LR, hepatocytes accumulate lipids, primarily triacylglycerol, and cholesterol esters, in the lipid droplets. Although it is widely accepted that this phenomenon contributes to LR, the impact of lipid droplet deposition on LR remains a matter of debate. Some studies have suggested that lipid droplet deposition has no effect or may even be detrimental to LR. This review article focuses on transient regeneration-associated steatosis and its relationship with the liver regenerative response.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Hepatology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Unveiling the power of microenvironment in liver regeneration: an in-depth overview;Frontiers in Genetics;2023-12-13

2. Lipid droplets in steatotic liver disease;Current Opinion in Clinical Nutrition & Metabolic Care;2023-11-16

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