Bloodstream Infections in Children Hospitalized for Influenza, the Canadian Immunization Monitoring Program Active (IMPACT)-Reference-Cited by-全球学者库

Bloodstream Infections in Children Hospitalized for Influenza, the Canadian Immunization Monitoring Program Active (IMPACT)

Published:2023-12-01 Issue: Volume: Page:
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Modler Jacqueline¹,Morris Shaun K.²,Bettinger Julie A.³,Bancej Christina⁴,Burton Catherine⁵,Foo Cheryl⁶,Halperin Scott A.⁷,Jadavji Taj⁸,Kazmi Kescha²,Sadarangani Manish³⁹,Schober Tilmann¹⁰¹¹,Papenburg Jesse¹¹⁰¹¹^ORCID,

Affiliation:

1. From the Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University, Montréal, Quebec, Canada

2. Division of Pediatric Infectious Diseases, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada

3. Vaccine Evaluation Center, BC Children’s Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

4. Center for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, Ontario, Canada

5. Division of Pediatric Infectious Diseases, Department of Paediatrics, Stollery Children’s Hospital, University of Alberta, Edmonton, Alberta, Canada

6. Pediatric Infectious Diseases, Janeway Children’s Health and Rehabilitation Centre, Eastern Health Regional Authority, St. John’s, Newfoundland and Labrador, Canada

7. Canadian Center for Vaccinology, IWK Health Center, Dalhousie University, Halifax, Nova Scotia, Canada

8. Section of Infectious Diseases, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada

9. Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada

10. Division of Pediatric Infectious Diseases, Department of Pediatrics, Montreal Children’s Hospital, McGill University Health Centre

11. Division of Microbiology, Department of Clinical Laboratory Medicine, McGill University Health Centre, Montréal, Quebec, Canada.

Abstract

Background: We aimed to estimate the proportion of children hospitalized for influenza whose illness was complicated by bloodstream infection, describe their clinical course, and identify the factors associated with bloodstream infection. Methods: We performed active surveillance for laboratory-confirmed influenza hospitalizations among children ≤16 years old at the 12 Canadian Immunization Monitoring Program Active hospitals, from the 2010–2011 to 2020–2021 influenza seasons. Factors associated with bloodstream infection were identified using multivariable logistic regression analyses. Results: Among 9179 laboratory-confirmed influenza hospital admissions, bloodstream infection occurred in 87 children (0.9%). Streptococcus pyogenes (22%), Staphylococcus aureus (18%) and Streptococcus pneumoniae (17%) were the most common bloodstream infection pathogens identified. Children with cancer [adjusted odds ratio (aOR): 2.78; 95% confidence interval (CI): 1.23–5.63], a laboratory-confirmed nonbloodstream bacterial infection (aOR: 14.1; 95% CI: 8.04–24.3) or radiographically-confirmed pneumonia (aOR: 1.87; 95% CI: 1.17–2.97) were more likely to experience a bloodstream infection, whereas children with chronic lung disorders were less likely (aOR: 0.41; 95% CI: 0.19–0.80). Disease severity markers such as intensive care unit admission (aOR: 2.11; 95% CI: 1.27–3.46), mechanical ventilation (aOR: 2.84; 95% CI: 1.63–4.80) and longer hospital length of stay (aOR: 1.02; 95% CI: 1.01–1.03) were associated with bloodstream infection. Bloodstream infection also increased the odds of death (aOR: 13.0; 95% CI: 4.84–29.1) after adjustment for age, influenza virus type and the presence of any at-risk chronic condition. Conclusions: Bloodstream infections, although infrequent, are associated with intensive care unit admission, mechanical ventilation, increased hospital length of stay and in-hospital mortality, thus requiring increased levels of care among pediatric influenza hospitalizations.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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