Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia-Reference-Cited by-同舟云学术

Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia

Published:2024-01-11 Issue:2 Volume:43 Page:e67-e70
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Carter Michael J.¹²³⁴^ORCID,Shrestha Sonu²³,O’Reilly Peter²³,Gurung Pallavi⁵,Gurung Meeru⁵,Thorson Stephen⁵,Kandasamy Rama⁶⁴^ORCID,Voysey Merryn²³^ORCID,O’Mahony Elizabeth²³,Kelly Sarah²³,Ansari Imran⁵,Shah Ganesh⁵,Amatya Puja⁵,Tcherniaeva Irina⁷,Berbers Guy⁷,Murdoch David R.⁸^ORCID,Pollard Andrew J.²³^ORCID,Shrestha Shrijana⁵^ORCID,Kelly Dominic F.²³^ORCID,

Affiliation:

1. Paediatric Intensive Care, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom

2. Oxford Vaccine Group, Department of Paediatrics, University of Oxford

3. NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

4. National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Sydney, Australia

5. Pediatric Research Group, Patan Academy of Health Sciences, Patan, Kathmandu, Nepal

6. Discipline of Paediatrics and Child Health, School of Clinical Medicine, University of New South Wales

7. Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands

8. Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand.

Abstract

We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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