Evaluation of Anti-Glycopeptidolipid-Core Immunoglobulin A Antibody Detection for the Diagnosis of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis

Author:

Willemse Samuel H.1ORCID,Oomens Marjolijn A.E.M.2,Karssemakers Luc H.E.13,Lindeboom Jerome A.14,Schreuder Willem H.13,Ho Jean-Pierre T.F.15,van der Kuip Martijn6,Vlaming Killian E.78,Kaptein Tanja M.8,de Lange Jan1

Affiliation:

1. From the Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center (UMC) and Academic Centre for Dentistry Amsterdam, University of Amsterdam, Amsterdam, the Netherlands

2. Department of Oral and Maxillofacial Surgery, Rijnstate Hospital, Arnhem, the Netherlands

3. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Amsterdam, the Netherlands

4. Department of Oral and Maxillofacial Surgery, Amstelland Hospital, Amstelveen, the Netherlands

5. Department of Oral and Maxillofacial Surgery, Northwest Clinics, Alkmaar, the Netherlands

6. Department of Pediatric Infectious Diseases and Immunology, Amsterdam UMC, Emma Children’s Hospital, University of Amsterdam, Amsterdam, the Netherlands

7. Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

8. Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.

Abstract

A multicenter cross-sectional diagnostic study was carried out including 45 children with nontuberculous mycobacterial cervicofacial lymphadenitis and controls. The tested immunoassay, detecting M. avium–specific anti-glycopeptidolipid-core immunoglobulin A antibodies, had inadequate diagnostic performance in the studied population and seems to be of no additional value in detecting cases of nontuberculous mycobacterial cervicofacial lymphadenitis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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