Effectiveness and Safety of Direct-acting Antivirals for Treatment of Adolescents With HCV/HIV Coinfection: Real-world Data From Europe-Reference-Cited by-同舟云学术

Effectiveness and Safety of Direct-acting Antivirals for Treatment of Adolescents With HCV/HIV Coinfection: Real-world Data From Europe

Published:2024-02-02 Issue: Volume: Page:
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Malik Farihah¹^ORCID,Crichton Siobhan²^ORCID,Plotnikova Yulia³,Latysheva Inga⁴,Samarina Anna⁵^ORCID,Pokorska-Śpiewak Maria⁶^ORCID,Gomez Marisa Navarro⁷^ORCID,Bailey Heather⁸^ORCID,Thorne Claire¹^ORCID,Judd Ali²^ORCID,Turkova Anna²^ORCID,Collins Intira Jeannie²^ORCID

Affiliation:

1. From the UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

2. Medical Research Council Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom

3. Irkutsk AIDS Centre, Irkutsk Regional Centre for the Prevention and Control of AIDS and Infectious Diseases (IOC AIDS), Russia

4. Republican Clinical Hospital of Infectious Diseases, Saint Petersburg, Russia

5. The City HIV Centre, Saint Petersburg, Russia

6. Department of Children’s Infectious Diseases, Medical University of Warsaw; Hospital of Infectious Diseases in Warsaw, Poland

7. Pediatric Infectious Diseases, Hospital Gregorio Marañón, IISGM, UCM, CIBERINFEC ISCIII, Madrid, Spain; and

8. Institute for Global Health, University College London, London, United Kingdom.

Abstract

We evaluated the effectiveness and safety of direct-acting antivirals in adolescents with hepatitis C (HCV)/HIV coinfection using pooled individual patient-level data from 5 European cohorts. Of 122 participants in follow-up from November 2013 to August 2021, 19 were treated <18 years of age; of 15 with HCV RNA available at/after 12 weeks post-treatment, all had sustained virologic response with acceptable safety. This evidence addresses an important gap in knowledge of treatment outcomes in adolescents with HCV/HIV coinfection in real-life settings.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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