Cefiderocol Red Wine Urine Syndrome in Pediatric Patients: A Multicenter Case Series-Reference-Cited by-全球学者库

Cefiderocol Red Wine Urine Syndrome in Pediatric Patients: A Multicenter Case Series

Published:2023-10-20 Issue: Volume: Page:
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Shapiro Kate¹²^ORCID,Ungar Stephanie P.³,Krugman Jessica³,McGarrity Orlagh⁴,Cross Shane J.⁵,Indrakumar Bairavi⁶,Hatcher James⁶,Ratner Adam J.³,Wolf Joshua¹²^ORCID

Affiliation:

1. From the Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee

2. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee

3. Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York

4. Department of Pharmacy, Great Ormond Street Hospital for Children, London, United Kingdom

5. Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee

6. Department of Microbiology, Great Ormond Street Hospital for Children, London, United Kingdom.

Abstract

Cefiderocol is a novel cephalosporin antibiotic with activity against multidrug-resistant gram-negative bacteria and limited pediatric experience. This case series describes 3 immunocompromised children receiving blood transfusion who developed benign red or purple urine with administration of cefiderocol. Interaction with iron from blood products is a possible mechanism. It is important to recognize this phenomenon and distinguish it from hematuria to avoid unnecessary diagnostic testing.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Microbiology (medical),Pediatrics, Perinatology and Child Health

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