CENTRAL NERVOUS SYSTEM INFECTION BY GROUP A STREPTOCOCCUS IN CHILDREN IN SPAIN (2019

CENTRAL NERVOUS SYSTEM INFECTION BY GROUP A STREPTOCOCCUS IN CHILDREN IN SPAIN (2019–2023)

Published:2024-06-25 Issue: Volume: Page:
ISSN:0891-3668
Container-title:Pediatric Infectious Disease Journal
language:en
Short-container-title:

Author:

Cobo-Vázquez Elvira¹²,Aguilera-Alonso David²³⁴^ORCID,Rello-Saltor Victoria⁵,Gamell Anna⁶,Mellado-Sola Isabel⁷,Oltra-Benavent Manuel⁸,Martín-Pedraz Laura⁹,Manzanares-Casteleiro Ángela¹⁰,Carrasco-Colom Jaime¹¹,Cervantes Eloisa⁶,Sanz-Santaeufemia Francisco¹²,Colino-Gil Elena¹³,Jiménez-Montero Beatriz¹⁴,Soto Beatriz¹⁵,Calvo Cristina⁴⁷,Saavedra-Lozano Jesús³⁴¹⁶,

Affiliation:

1. From the Department of Pediatrics, Hospital Universitario Fundación de Alcorcón, Alcorcón

2. PhD Program in Medicine, Universidad Complutense de Madrid

3. Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)

4. Centro de Investigación Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

5. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron

6. Pediatrics and Infectious Diseases Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain

7. Department of Infectious Diseases and Tropical Pediatrics, Hospital Universitario La Paz and IdiPaz Foundation, Universidad Autónoma de Madrid, Red de Investigación Traslacional en Infectología Pediátrica (RITIP), Madrid, Spain

8. Department of Pediatrics, Hospital Universitario y Politécnico La Fe, Valencia, Spain

9. Department of Pediatrics, Complejo Hospitalario Regional de Málaga, Málaga, Spain

10. Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain

11. Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitari Son Espases, Palma de Mallorca, Spain

12. Department of Pediatrics, Hospital Universitario Niño Jesús, Madrid, Spain

13. Department of Pediatrics, Complejo Hospitalario Materno-Insular, Las Palmas de Gran Canaria, Spain

14. Department of Pediatrics, Hospital Universitario Marqués de Valdecilla, Santander, Spain

15. Department of Pediatrics, Hospital Universitario de Getafe, Getafe; and

16. Universidad Complutense de Madrid, Madrid, Spain.

Abstract

Central nervous system infections in children caused by group A Streptococcus are rare. This study, conducted across 52 hospitals in Spain from 2019 to 2023, identified 32 cases of central nervous system infections in children caused by group A Streptococcus, with a significant increase from October 2022 onward (1.1% vs. 5.9%, P = 0.002). Half required pediatric intensive care unit admission, 12.5% exhibited sequelae and the mortality rate was 6.2%. Mastoiditis was the predominant primary infection.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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