Eligibility of C-BIOPRED severe asthma cohort for type-2 biologic therapies

Author:

Deng Zhenan1,Jin Meiling2,Ou Changxing3,Jiang Wei4,Zhao Jianping5,Liu Xiaoxia6,Sun Shenghua7,Tang Huaping8,He Bei9,Cai Shaoxi10,Chen Ping11,Wu Penghui1,Liu Yujing4,Kang Jian12,Zhang Yunhui13,Huang Mao14,Xu Jinfu15,Huang Kewu16,Li Qiang17,Zhang Xiangyan18,Fu Xiuhua19,Wang Changzheng20,Shen Huahao21,Zhu Lei2,Shi Guochao22,Qiu Zhongmin23,Wen Zhongguang24,Wei Xiaoyang25,Gu Wei26,Wei Chunhua27,Wang Guangfa28,Chen Ping29,Xie Lixin30,Lin Jiangtao31,Tang Yuling32,Han Zhihai33,Chung Kian Fan3435,Zhang Qingling1,Zhong Nanshan1,

Affiliation:

1. Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China

2. Department of Respiratory Medicine, Zhongshan Hospital, Shanghai 200433, China

3. Guangzhou Medical University, Guangzhou, Guangdong 510180, China

4. AstraZeneca, Shanghai 200085, China

5. Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

6. Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

7. Department of Respiratory Medicine, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China

8. Department of Respiratory Medicine, Qingdao Municipal Hospital, Qingdao, Shandong 266001, China

9. Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China

10. Department of Respiratory Medicine, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong 510515, China

11. Department of Respiratory Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, China

12. Department of Respiratory Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China

13. Department of Respiratory Medicine, The First people's Hospital of Yunnan Province, Kunming, Yunnan 363880, China

14. Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China

15. Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Shanghai 200433, China

16. Department of Respiratory Medicine, Beijing Chao-Yang Hospital, Beijing 100020, China

17. Department of Respiratory Medicine, Shanghai General Hospital, Shanghai 200080, China

18. Department of Respiratory Medicine, Guizhou Province People's Hospital, Guiyang, Guizhou 550002, China

19. Department of Respiratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia 010050, China

20. Department of Respiratory Medicine, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China

21. Department of Respiratory Medicine, The Second Affiliated hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China

22. Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

23. Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China

24. Department of Respiratory Medicine, The First Affiliated Hospital of PLA General Hospital, Beijing 100048, China

25. Department of Respiratory and Critical Care Medicine, The Eighth Medical Center of PLA General Hospital, Beijing 100048, China

26. Department of Respiratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China

27. Department of Respiratory Medicine, Weifang Weien Hospital, Weifang, Shandong 261045, China

28. Department of Respiratory Medicine, Peking University First Hospital, Beijing 100034, China

29. Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China

30. College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing 100853, China

31. Department of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China

32. Department of Respiratory Medicine, The First Hospital of Changsha, Changsha, Hunan 410005, China

33. Deparment of Pulmonary and Critical Care Medicine, The Sixth Medical Center of PLA General Hospital, Beijing 100048, China

34. National Heart and Lung Institute, Imperial College London, London SW3, UK

35. Royal Brompton and Harefield NHS Foundation Trust, London SW3, UK.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine,General Medicine

Reference5 articles.

1. Management of severe asthma: a European Respiratory Society/American Thoracic Society Guideline;Holguin;Eur Respir J,2020

2. A survey on clinical characteristics and risk factors of severe asthma in China (in Chinese);Wang;Nat Med J China,2020

3. Severe eosinophilic asthma in Chinese C-BIOPRED asthma cohort;Zhang;Clin Transl Med,2022

4. T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin;Pavlidis;Eur Respir J,2019

5. Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma;Rossios;J Allergy Clin Immunol,2018

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