FTY720, A Novel Immunomodulator: Efficacy and Safety Results from the First Phase 2A Study in de novo Renal Transplantation

Author:

Tedesco-Silva Helio,Mourad Georges,Kahan Barry D.,Boira Josep Grinyo,Weimar Willem,Mulgaonkar Shamkant,Nashan Björn,Madsen Soren,Charpentier Bernard,Pellet Pascale,Vanrenterghem Yves

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Transplantation

Reference23 articles.

1. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: discovery of a novel immunosuppressant, FTY720.;Adachi;Bioorg Med Chem Lett,1995

2. FTY720, a novel immunosuppressant, induces sequestration of circulating lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing.;Chiba;J Immunol,1998

3. FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines.;Chen;Transplant Proc,2001

4. FTY720: targeting G protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.;Brinkmann;Curr Opin Immunol,2002

5. FTY720, a novel immunosuppressant, shows a synergistic effect in combination with FK506 in rat allograft models.;Hoshino;Transplant Proc,1999

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