White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder-Reference-Cited by-同舟云学术

White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder

Published:2023-05-08 Issue:4 Volume:33 Page:160-163
ISSN:0955-8829
Container-title:Psychiatric Genetics
language:en
Short-container-title:

Author:

Zai Gwyneth¹²³,Zai Clement C.¹²³⁴⁵,Arnold Paul D.⁶⁷,Richter Margaret A.²³⁸,Hanna Gregory L.⁹,Rosenberg David¹⁰,Kennedy James L.¹²³

Affiliation:

1. Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health

2. Department of Psychiatry, University of Toronto

3. Institute of Medical Science, Faculty of Medicine, University of Toronto

4. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

5. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

6. The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

7. Program in Genetics and Genomic Biology and Department of Psychiatry, The Hospital for Sick Children

8. Department of Psychiatry, Frederick W. Thompson Anxiety Disorders Centre, Sunnybrook Health Science Centre, Toronto, ON, Canada

9. Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA

10. Department of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA

Abstract

The myelin oligodendrocyte glycoprotein (MOG) gene plays an important role in myelination and has been implicated in the genetics of white matter changes in obsessive-compulsive disorder (OCD). We examined the association between variations of two microsatellite markers across MOG for association and total white matter volume as measured using volumetric MRI in 37 pediatric OCD patients 7–18 years. We compared white matter volumes between microsatellite allele groups using analysis of covariance with covariates of age, gender, and total intracranial volume. After controlling for multiple comparisons, a significant relationship was detected between MOG (TAAA)n and increased total white matter volume (P = 0.018–0.028). Although preliminary, our findings provide further support for the involvement of MOG in OCD.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Biological Psychiatry,Psychiatry and Mental health,Genetics (clinical),Genetics

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