18F-FDG PET/CT of Brown Adipose Tissue Hyperactivation Associated With Pregnancy and Paraganglioma

Author:

Maffione Anna Margherita1,Rampin Lucia1,Chondrogiannis Sotirios1,Marzola Maria Cristina1,Colletti Patrick M.1,Rubello Domenico1

Affiliation:

1. From the *Nuclear Medicine and PET Department, Santa Maria della Misericordia Hospital, Rovigo, Italy; and † Department of Radiology, University of Southern California, Los Angeles, CA.

Abstract

Abstract This 32-year-old woman presented with pregnancy-related arterial hypertension unresponsive to antihypertensive therapy. During cesarean delivery, a lobulated retroperitoneal mass was discovered. 18F-FDG PET/CT performed 18 days postpartum demonstrated the hyperactive retroperitoneal mass and extensive hyperactivated brown adipose tissue. The mass was surgically removed, revealing a para-aortic multicentric paraganglioma. After surgery, blood pressure normalized, and serum chromogranin A and urinary metanephrines normalized. Brown adipose tissue hypermetabolism disappeared on follow-up FDG PET. Her initial FDG PET demonstrated brown adipose tissue hyperactivation, which may have been caused by the combination of hormonal changes in pregnancy and the paraganglioma.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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