Effect of Nasal Septoplasty on Fibrinogen/HDL Ratio in Patients With Nasal Septal Deviation

Abstract

Objective: The present study aimed to investigate the plasma fibrinogen/high-density lipoprotein (HDL) ratio in patients with marked nasal septal deviation (NSD) and to evaluate the effect of septoplasty on this ratio. Methods: The present prospective study included 56 patients who had a septoplasty due to a marked NSD (NSD group) in an academic tertiary hospital and 40 age-matched and sex-matched healthy volunteers (control group) between April 2019 and December 2021. The diagnosis of marked NSD was performed via a detailed otorhinolaryngological examination, nasal endoscopy, and computed tomography finding. All patients in the NSD group were evaluated for plasma fibrinogen, HDL, mean platelet volume (MPV), platelet distribution width (PDW), and fibrinogen/HDL values before and 3 months after surgery, and preoperative values were compared with the control group. Preoperative and postoperative fibrinogen, HDL, MPV, PDW, and fibrinogen/HDL values were also compared in the NSD group. Results: There was no significant difference between the NSD and control groups regarding age, sex, fibrinogen, HDL, MPV, PDW, and fibrinogen/HDL values. Fibrinogen, MPV, and fibrinogen/HDL values were significantly decreased, whereas HDL levels significantly increased after septoplasty in the NSD group. There was no significant difference in terms of preoperative and postoperative PDW values. Conclusion: To the best of our knowledge, this is the first study investigating the fibrinogen/HDL ratio and the effect of septoplasty on this ratio in NSD in the literature. In the present study, the fibrinogen/HDL ratio was significantly decreased after septoplasty in patients with NSD, which may be attributed to the therapeutic effect of nasal septoplasty on the restoration of hypercoagulopathy provoked by chronic hypoxia.