Quantification of the O- and N-Demethylated and the Glucuronidated Metabolites of Codeine Relative to the Debrisoquine Metabolic Ratio in Urine in Ultrarapid, Rapid, and Poor Debrisoquine Hydroxylators-Reference-Cited by-同舟云学术

Quantification of the O- and N-Demethylated and the Glucuronidated Metabolites of Codeine Relative to the Debrisoquine Metabolic Ratio in Urine in Ultrarapid, Rapid, and Poor Debrisoquine Hydroxylators

Published:1997-10 Issue:5 Volume:19 Page:539-542
ISSN:0163-4356
Container-title:Therapeutic Drug Monitoring
language:en
Short-container-title:Therapeutic Drug Monitoring

Author:

Yue Q. Y.,Alm C.,Svensson J. O.,Säwe J.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

1. A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine.

2. Plasma concentrations of codeine and its metabolite, morphine, after single and repeated oral administration

3. Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation.

4. Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

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