Affiliation:
1. AU/UGA Medical Partnership, Athens, GA
Abstract
Abstract
Monoclonal antibodies (mabs) and small molecule Janus kinase (JAK) inhibitors (nibs) are useful for treating inflammatory disease, autoimmune disease, and tumors, especially leukemia. Inhibition or depletion of the cytokines or cells with these drugs can result in loss of important protection against certain microbial infections. Recurrences of tuberculosis, hepatitis B and C, and zoster are especially sensitive to immune depletion. The consequences of inhibition of cytokines, molecules, pathways and cells by these drugs are described, depicted, and tabulated.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Infectious Diseases,Microbiology (medical)