Autophagy in hepatic macrophages can be regulator and potential therapeutic target of liver diseases: A review

Author:

Ge Jun12,Li Hao1,Yang Jia-Qi2,Yue Yuan2,Lu Sheng-Yu2,Nie Hong-Yun2,Zhang Tao1,Sun Pei-Ming1,Yan Hong-Feng1,Sun Hong-Wei1,Yang Jian-Wu1,Zhou Jin-Lian3,Cui Yan12ORCID

Affiliation:

1. Department of General Surgery, Strategic Support Force Medical Center, Beijing 100101, China

2. Department of General Surgery, The 306th Hospital of PLA-Peking University Teaching Hospital, Beijing 100101, China

3. Department of Pathology, Strategic Support Force Medical Center, Beijing 100101, China.

Abstract

Hepatic macrophages are a complex population of cells that play an important role in the normal functioning of the liver and in liver diseases. Autophagy, as a maintainer of cellular homeostasis, is closely connected to many liver diseases. And its roles are not always beneficial, but manifesting as a double-edged sword. The polarization of macrophages and the activation of inflammasomes are mediated by intracellular and extracellular signals, respectively, and are important ways for macrophages to take part in a variety of liver diseases. More attention should be paid to autophagy of hepatic macrophages in liver diseases. In this review, we focus on the regulatory role of hepatic macrophages’ autophagy in a variety of liver diseases; especially on the upstream regulator of polarization and inflammasomes activation of the hepatic macrophages. We believe that the autophagy of hepatic macrophages can become a potential therapeutic target for management of liver diseases.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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