Aplastic anemia from past to the present: A bibliometric analysis with research trends and global productivity during 1980 to 2022

Author:

Bulduk Tuba1ORCID

Affiliation:

1. Gülhane Education and Training Hospital, Faculty of Medicine, Department of Hematology, Ankara, Turkey.

Abstract

There is no bibliometric study in the literature on Aplastic Anemia (AA). In the present study, the purpose was to summarize the intellectual structure of the subject, uncover the global productivity in this respect, and identify the latest research trends by performing a bibliometric analysis of the articles published on AA. For this purpose, outputs for different research components of scientific outputs (i.e., countries, institutions, journals, and authors) were analyzed. A total of 3221 articles on Aplastic Anemia published between 1980 and 2022 were analyzed by using various statistical methods and bibliometric approaches. The Spearman Correlation Coefficient was used for correlation analysis and bibliometric network visualization maps were used to identify trending topics, citation analysis, and international collaborations. The top 3 contributing countries to the literature were the USA in this respect (800, 24.8%), China (514, 15.9%), and Japan (442, 13.7%). The top 3 most active institutions were the National Institutes of Health USA (n = 177), National Heart Lung Blood Institute (n = 153), and Udice French Research Universities (n = 136). The top 3 most productive journals were the British Journal of Haematology (n = 239), Blood (n = 181), and Bone Marrow Transplantation (n = 137). The most prolific author was Neal Stuart Young (n = 130). Specific keywords that were most frequently used in articles were severe aplastic anemia, immunosuppressive therapy, pediatrics/children, anti-thymocyte globulin, cyclosporine, hematopoietic stem cell transplantation, myelodysplastic syndromes, Paroxysmal Nocturnal Hemoglobinuria, hepatitis-associated aplastic anemia, allogeneic stem cell transplantation, haploidentical hematopoietic stem cell transplantation, pancytopenia, eltrombopag, fludarabine, Graft-Versus-Host Disease, survival, apoptosis, cytokines, and cyclophosphamide. It was determined that the trend topics in recent years were eltrombopag, COVID-19, Treg, Th17, thrombopoietin receptor agonists, haploidentical hematopoietic stem cell transplantation, haploidentical donor/transplantation, and posttransplantation cyclophosphamide. In the formation of the AA literature, it was determined that the research leadership belonged to the USA, China, Japan, European countries (United Kingdom, Italy, Germany, France, Switzerland), India, and South Korea, which have large economies.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

Reference29 articles.

1. Aplastic anemia: pathophysiology.;Giudice;Semin Hematol,2022

2. Ueber einem Fall von anämie mit Bemerkungen über rejenerative veränderungen des knochenmarks.;Ehrlich;Charité-Annalen,1888

3. Current concepts in the pathophysiology and treatment of aplastic anemia.;Young;Blood,2006

4. Treatment of acquired severe aplastic anemia: bone marrow transplantation compared with immunosuppressive therapy-the European group for blood and marrow transplantation experience.;Bacigalupo;Semin Hematol,2000

5. Guidelines for the diagnosis and management of aplastic anaemia.;Marsh;Br J Haematol,2009

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