Orbital adenoid cystic carcinoma treated by radiotherapy combined with anlotinib in a 13-year-old girl: A case report

Author:

Wu Xue12ORCID,Qiao Lili2,Tian Tiantian2,Shu Yang3,Zhang Yingying24

Affiliation:

1. Clinical Medical College of Jining Medical University, Jining, Shandong Province, China

2. Department of Radiation Oncology, The First Affiliated Hospital of Shandong First Medical University, Changsha, China

3. Shandong University of Traditional Chinese Medicine, Jining, Shandong Province, China

4. Cheeloo College of Medicine, Shandong University Jining, Shandong Province, China.

Abstract

Rationale: Adenoid cystic carcinoma (ACC) of orbit is a very rare epithelial tumor, often originating from the lacrimal glands. At the same time, treatment options are currently limited, such as radiation, chemotherapy. We report a case of a patient treated with antirotinib combined with radiotherapy. Patient concerns: A 13-year-old girl was initially admitted with “left eye swelling for over half a year, 12 days after surgery for left orbital adenoid cystic carcinoma”. Initial swelling of the lateral upper eyelid of the left eye, with gradual enlargement and occasional pain. Diagnoses: Left orbital adenoid cystic carcinoma. Interventions: After diagnosis of orbital ACC, she underwent resection of the left orbital mass, and received 33 times of adjuvant radiotherapy, but brain metastases appeared later. She refused further treatment, and received 25 times of radiotherapy and anlotinib therapy after the disease progressed again. Outcomes: Now the patient has been followed up for 8 months, but no progress was found. Lessons: Based on this, we hypothesized that radiation therapy in combination with anlotinib is effective for ACC or ACC metastases.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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