Affiliation:
1. Department of Neurology, Taizhou Municipal Hospital, Taizhou, Zhejiang, China.
Abstract
Objective:
To analyze the correlation between circulating homocysteine (Hcy) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and poststroke depression (PSD).
Materials and methods:
Chinese (Chinese National Knowledge Infrastructure, Wanfang, and VIP) and English (PubMed, EMBASE, MEDLINE, and Cochrane Library) databases on the correlation between circulating Hcy and Lp-PLA2 and PSD were collected. Meta-analysis was performed to compare the distinctions in circulating Hcy and Lp-PLA2 levels between PSD and non-PSD groups. Meta-analysis was conducted by using STATA 15.0 software.
Results:
A total of 20 literatures were included in this study. The level of circulating Lp-PLA2 in the PSD group was obviously higher than that in the non-PSD group (weighted mean differences: 2.75, 95%CI: 0.10–5.39, P = .002), which was an independent predictor of PSD (effect size = 0.05, 95%CI: 0.03, 0.07, P < .001). The level of circulating Hcy in the PSD group was obviously higher than that in the non-PSD group (weighted mean differences = 1.41, 95%CI: 1.01, 1.81, P < .001), which was an independent influencing factor for the occurrence of PSD (effect size = 0.07, 95%CI: 0.04, 0.09, P = .011).
Conclusion:
Circulating Hcy and Lp-PLA2 levels are linked to the development of PSD, and can be applied as predictive or diagnostic indicators.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference42 articles.
1. Global burden of stroke.;Feigin;Circ Res,2017
2. Incidence, risk factors, prognosis, and health-related quality of life after stroke in a low-resource community in Chile (ÑANDU): a prospective population-based study.;Lavados;Lancet Glob Health,2021
3. Neuropsychiatric sequelae of stroke.;Ferro;Nat Rev Neurol,2016
4. The cognitive, emotional, and social sequelae of stroke: psychological and ethical concerns in post-stroke adaptation.;Mukherjee;Top Stroke Rehabil,2006
5. Systemic inflammation after stroke: implications for post-stroke comorbidities.;Simats;EMBO Mol Med,2022