Affiliation:
1. Department of Traditional Chinese Medicine, Wuhan No.1 Hospital, Wuhan, China
2. Department of Gynaecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China
3. Department of Geriatrics, The Central Hospital of Xianning, Xianning, China.
Abstract
Background:
This systemic review and meta-analysis seeks to systematically analyze and summarize the association between non-coding RNA polymorphisms and ovarian cancer risk.
Methods:
We searched PubMed, Web of Science and CNKI for available articles on non-coding RNA polymorphisms in patients with ovarian cancer from inception to March 1, 2023. The quality of each study included in the meta-analysis was rated according to the Newcastle–Ottawa Scale.
Odds ratios (ORs) with their 95% confidence intervals (95% CI) were used to assess associations. Chi-square Q-test combined with inconsistency index (I2) was used to test for heterogeneity among studies. Lastly, trial sequential analysis (TSA) software was used to verify the reliability of meta-analysis results, and in-silico miRNA expression were also performed. The meta-analysis was registered with PROSPERO (No. CRD42023422091).
Results:
A total of 17 case-control studies with 18 SNPs were selected, including 2 studies with H19 rs2107425 and HOTAIR rs4759314, and 5 studies with miR-146a rs2910164 and miR-196a rs11614913. Significant associations were found between H19 rs2107425, miR-146a rs2910164, and miR-196a rs11614913 and ovarian cancer risk. Three genetic models of H19 rs2107425 (CT vs TT (heterozygote model): OR = 1.36, 95% CI = 1.22–1.52, P < .00001; CC + CT vs TT (dominant model): OR = 1.12, 95% CI = 1.02–1.24, P = .02; and CC vs CT + TT (recessive model): OR = 1.23, 95% CI = 1.16–1.31, P < .00001), 2 genetic models of miR-146a rs2910164 (allele model: OR = 1.75, 95% CI = 1.05–2.91, P = .03; and heterozygote model: OR = 0.33, 95% CI = 0.11–0.98, P = .05), 3 genetic models of miR-196a rs11614913 (allele model: OR = 0.70, 95% CI = 0.59–0.82, P < .0001; dominant model: OR = 1.62, 95% CI = 1.18–2.24, P = .0001; and recessive model: OR = 0.70, 95% CI = 0.57–0.87, P = .03) were statistically linked to ovarian cancer risk. Subgroup analysis for miR-146a rs2910164 was performed according to ethnicity. No association was found in any genetic model. The outcomes of TSA also validated the findings of this meta-analysis.
Conclusion:
This study summarizes that H19 rs2107425, miR-146a rs2910164, and miR-196a rs11614913 polymorphisms are significantly linked with the risk of ovarian cancer, and moreover, large-scale and well-designed studies are needed to validate our result.
Publisher
Ovid Technologies (Wolters Kluwer Health)