Reversal of nonalcoholic fatty liver disease reduces the risk of cardiovascular disease among Korean

Author:

Oh Yun Hwan12,Jeong Seogsong3,Park Sun Jae4,Ahn Joseph C5,Park Sang Min46ORCID

Affiliation:

1. Department of Family Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, South Korea

2. Department of Family Medicine, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, South Korea

3. Department of Biomedical Informatics, CHA University School of Medicine, Seongnam, South Korea

4. Department of Biomedical Sciences, Seoul National University, Seoul National University College of Medicine, Seoul, South Korea

5. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN

6. Department of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is considered an independent risk factor for the development of cardiovascular disease. However, the association between changes in NAFLD status and the risk of cardiovascular disease (CVD) remains uncertain. Starting January 1, 2013, participants were followed until the occurrence of CVD event, death, or December 31, 2020. This was a population-based cohort study that included data from adults aged ≥ 20, who underwent 2 consecutive health screenings from 2009 to 2012. NAFLD was defined as a Fatty Liver Index ≥ 60 at each screening. The primary endpoint was a CVD event, which encompassed ischemic heart disease and cerebrovascular disease. The association between changes in NAFLD status and the risk of CVD was determined using multivariable Cox proportional hazards regression. This cohort comprised 4656,305 adults with a median age of 53 years. During 36,396,968 person-years of follow-up, 238,933 (5.1%) CVD events were observed. Compared to patients with no NAFLD at both screenings, patients who developed NAFLD at the second screening exhibited an increased risk of CVD (adjusted hazard ratio, 1.15; 95% confidence interval, 1.13–1.17). In contrast, individuals who recovered from NAFLD at the second screening demonstrated a reduced CVD risk compared to those with persistent NAFLD (adjusted hazard ratio, 0.91; 95% confidence interval, 0.90–0.92). The reversal of NAFLD is associated with a reduced risk of CVD. Therefore, focusing on NAFLD treatment could serve as a clinical target for lowering CVD risk.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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