Analysis of factors related to thrombosis in patients with PICC placements

Abstract

This study aimed to investigate the conditions of patients with peripherally inserted central catheter (PICC) placements, analyze the risk factors influencing thrombosis in PICC-placed patients, and formulate more accurate and effective PICC management strategies. A total of 147 patients undergoing PICC placements were selected as the study subjects. Clinical data were collected, and the patients were divided into thrombosis and non-thrombosis groups. Detect levels of bilirubin, white blood cells, venous pressure, heparin concentration, blood flow, citric acid, and platelets. Pearson chi-square test, Spearman correlation analysis, as well as univariate and multivariate logistic regression were employed to analyze independent risk factors. Among the 147 patients with PICC placements, there were 84 males and 63 females. Thrombosis occurred in 116 cases, with an incidence rate of 78.91%. Pearson chi-square test showed a significant correlation between citric acid, blood flow, platelets and frailty (P < .001) with thrombosis formation. Spearman correlation analysis revealed a significant correlation between citric acid (ρ = −0.636, P < .001), blood flow (ρ = 0.584, P < .001), platelet count (ρ = 0.440, P < .001), frailty (ρ = −0.809, P < .001) and thrombosis in PICC placement patients. Univariate logistic regression analysis indicated a significant correlation between thrombosis formation and citric acid (OR = 0.022, 95% CI = 0.006–0.08, P < .001), blood flow (OR = 33.973, 95% CI = 9.538–121.005, P < .001), platelet count (OR = 22.065, 95% CI = 5.021–96.970, P < .001), frailty (OR = 0.003, 95% CI = 0.001–0.025, P < .001). Multivariate logistic regression analysis also showed a significant correlation between thrombosis formation and citric acid (OR = 0.013, 95% CI = 0.002–0.086, P < .001), blood flow (OR = 35.064, 95% CI = 6.385–192.561, P < .001), platelet count (OR = 4.667, 95% CI = 0.902–24.143, P < .001), frailty (OR = 0.006, 95% CI = 0.001–0.051, P < .001). However, gender (OR = 0.544, 95% CI = 0.113–2.612, P = .447), age (OR = 4.178, 95% CI = 0.859–20.317, P = .076), bilirubin (OR = 2.594, 95% CI = 0.586–11.482, P = .209), white blood cells (OR = 0.573, 95% CI = 0.108–3.029, P = .512), venous pressure (OR = 0.559, 95% CI = 0.129–2.429, P = .438), and heparin concentration (OR = 2.660, 95% CI = 0.333–21.264, P = .356) showed no significant correlation with thrombosis formation. Patients with PICC placements have a higher risk of thrombosis, citric acid, blood flow, platelet count and frailty are the main risk factors.