Development of a standard set of data variables and a database platform for panvascular disease

Abstract

Panvascular disease has emerged as a growing disease burden worldwide, highlighting the requirement of advanced research based on a holistic perspective. Establishing a standard set of data variables for clinical research on epidemiology, risk evaluation, diagnostic strategy, the efficacy of therapeutics, and care quality monitoring is paramount. A multidisciplinary working group consisting of 12 experts developed a standardized data variables and definitions through a systemic review and analysis of major domestic and international guidelines, clinical research articles, and standard terminologies in conjunction with data on Chinese clinical treatment and practice and research needs. A total of 555 data variables were included, among which 129 were mandatory. The key domains based on the timeline of care delivery are as follows: (1) demographics, (2) patient characteristics and comorbidities, (3) presentation details, (4) laboratory testing, (5) non-invasive tests, (6) invasive procedures/operations, (7) pre-discharge review, (8) risk assessment, and (9) follow-up. Patients with atherosclerotic cardiovascular disease, subclinical atherosclerosis, and high-risk factors are eligible for enrollment into the database. As of March 31, 2023, a total of 20 participating hospitals have started collecting patient data. A total of 2,106 patients have been enrolled.