Examining the interim proposal for name change to steatotic liver disease in the US population

Author:

Ng Cheng Han1ORCID,Chan Kai En1,Muthiah Mark123,Tan Caitlyn1,Tay Phoebe1,Lim Wen Hui1,Tan Darren Jun Hao1,Fu Clarissa Elysia1,Yong Jie Ning1,Wong Zhen Yu4,Koh Benjamin1,Chew Nicholas WS15,Syn Nicholas16,Huang Daniel Q.123,Dan Yock Young123,Siddiqui Mohammad S.7,Sanyal Arun J.7,Noureddin Mazen8ORCID

Affiliation:

1. Yong Loo Lin School of Medicine, National University of Singapore, Singapore

2. Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore

3. National University Centre for Organ Transplantation, National University Health System, Singapore

4. Nottingham University Hospitals NHS Trust, Nottingham, England, UK

5. Department of Cardiology, National University Heart Centre, National University Hospital, Singapore

6. Department of General Surgery, Singapore General Hospital, Singapore

7. Division of Gastroenterology, Department of Internal Medicine, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA

8. Houston Research Institute, Houston, Texas, USA

Abstract

Background and Aims: Fatty liver is the commonest liver condition globally and traditionally associated with NAFLD. A consensus meeting was held in Chicago to explore various terminologies. Herein, we explore the proposed changes in nomenclature in a population data set from the US. Approach and Results: Statistical analysis was conducted using survey-weighted analysis. Assessment of fatty liver was conducted with vibration-controlled transient elastography. A controlled attenuation parameter of 288 dB/m was used to identify hepatic steatosis. Patients were classified into nonalcoholic steatotic liver disease, alcohol-associated steatotic liver disease, and viral hepatitis steatotic liver disease. Liver stiffness measures at ≥8.8, ≥11.7, and ≥14 kPa were used to identify clinically significant fibrosis, advanced fibrosis, and cirrhosis, respectively. A total of 5102 individuals were included in the analysis. Using a survey-weighted analysis, a total of 25.43%, 6.95%, and 0.73% of the population were classified as nonalcoholic steatotic liver disease, alcohol-associated steatotic liver disease, and viral hepatitis steatotic liver disease, respectively. A sensitivity analysis at controlled attenuation parameter of 248 dB/m and fatty liver index found similar distribution. In a comparison between nonalcoholic steatotic liver disease, alcohol-associated steatotic liver disease, and viral hepatitis steatotic liver disease, there was no significant difference between the odds of advanced fibrosis and cirrhosis between groups. However, viral hepatitis steatotic liver disease individuals were found to have a significantly higher odds of clinically significant fibrosis (OR: 3.76, 95% CI, 1.27–11.14, p=0.02) compared with nonalcoholic steatotic liver disease. Conclusions: The current analysis assessed the proposed changes based on discussions from the consensus meeting. Although the definitions are an interim analysis of discussions, steatotic liver disease respects the underlying liver etiology and reduces stigma while increasing awareness of FL among viral and alcohol-associated steatosis/steatohepatitis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Hepatology

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3