A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components-Reference-Cited by-同舟云学术

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

Published:2020-09-02 Issue:559 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Nilsson Monique B.¹^ORCID,Sun Huiying¹^ORCID,Robichaux Jacqulyne¹^ORCID,Pfeifer Matthias²^ORCID,McDermott Ultan²^ORCID,Travers Jon²,Diao Lixia³^ORCID,Xi Yuanxin³,Tong Pan³,Shen Li³,Hofstad Mia¹^ORCID,Kawakami Masanori¹,Le Xiuning¹,Liu Xi¹,Fan Youhong¹^ORCID,Poteete Alissa¹^ORCID,Hu Limei¹,Negrao Marcelo V.¹^ORCID,Tran Hai¹^ORCID,Dmitrovsky Ethan¹,Peng David¹^ORCID,Gibbons Don L.¹^ORCID,Wang Jing³^ORCID,Heymach John V.¹^ORCID

Affiliation:

1. Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Oncology R&D, AstraZeneca, Cambridge, CB2 0RE, UK.

3. Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

YAP and FOXM1 are mediators of EGFR inhibitor resistance, and spindle proteins are therapeutic targets for this multidrug-resistant phenotype.

Funder

National Institutes of Health

National Cancer Institute

LUNGevity Foundation

University of Texas MD Anderson Cancer Center

Publisher