Reduced pannexin 1–IL-33 axis function in donor livers increases risk of MRSA infection in liver transplant recipients

Author:

Li Hao1ORCID,Yu Xiaoyu2ORCID,Shi Baojie34ORCID,Zhang Kun34,Yuan Liyun5ORCID,Liu Xueni1ORCID,Wang Pusen1,Lv Junwei1,Meng Guangxun6,Xuan Qiankun2,Wu Wenjuan2,Li Bin7ORCID,Peng Xiao8,Qin Xuebin8910ORCID,Liu Wanqing11ORCID,Zhong Lin1ORCID,Peng Zhihai134ORCID

Affiliation:

1. Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

2. Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200085, China.

3. Department of General Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, China.

4. Organ Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen 361000, China.

5. Bio-Med Big Data Center, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

6. Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

7. Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

8. Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 10140, USA.

9. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

10. Department of Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.

11. Department of Pharmaceutical Sciences and Department of Pharmacy, Wayne State University, Detroit, MI 48201, USA.

Abstract

PANX1 modulates innate immunity in the liver via the ATP–P2X2–NLRP3–IL-33 axis and is a therapeutic target for posttransplantation MRSA infection.

Funder

Natural Science Foundation of Shanghai

National Natural Science Foundation of China

the Medical Engineering Crossing Project Grant Funded by Shanghai Jiao Tong University

National Science and Technology Major Project of China Grants

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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