Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration-Reference-Cited by-同舟云学术

Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

Published:2021-01-27 Issue:578 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lei Qian¹^ORCID,Gao Fei²^ORCID,Liu Teng³^ORCID,Ren Wenxiang²,Chen Li⁴,Cao Yulin²,Chen Wenlan²,Guo Shaojun²,Zhang Qiong³,Chen Weiqun⁴,Wang Hongxiang⁴,Chen Zhichao²,Li Qiubai²^ORCID,Hu Yu²^ORCID,Guo An-Yuan³^ORCID

Affiliation:

1. Institute of Hematology, Union Hospital, Tongji Medical College, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430022, China.

2. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

3. Center for Artificial Intelligence Biology, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

4. Department of Hematology, Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.

Abstract

Umbilical cord MSC–derived extracellular vesicles rejuvenate aged bone marrow MSCs and slow age-related degeneration in mice.

Funder

National Key Research and Development Program of China Stem Cell and Translational Research

National Natural Science Foundation of China

China Postdoctoral Science Foundation funded project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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1. From discoveries in ageing research to therapeutics for healthy ageing