Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis-Reference-Cited by-同舟云学术

Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis

Published:2020-09-30 Issue:563 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chakraborty Debomita¹^ORCID,Zhu Honglin¹²^ORCID,Jüngel Astrid³^ORCID,Summa Lena¹,Li Yi-Nan¹^ORCID,Matei Alexandru-Emil¹^ORCID,Zhou Xiang¹,Huang Jingang¹,Trinh-Minh Thuong¹,Chen Chih-Wei¹^ORCID,Lafyatis Robert⁴^ORCID,Dees Clara¹,Bergmann Christina¹^ORCID,Soare Alina¹,Luo Hui²^ORCID,Ramming Andreas¹^ORCID,Schett Georg¹^ORCID,Distler Oliver³^ORCID,Distler Jörg H. W.¹^ORCID

Affiliation:

1. Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany.

2. Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

3. Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, 8091 Zürich, Switzerland.

4. Department of Medicine, University of Pittsburgh, PA 15261, USA.

Abstract

Up-regulation of FGFR3 and FGF9 induces profibrotic pathways promoting fibroblast activation and tissue fibrosis in systemic sclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference88 articles.

1. Mechanisms of fibrosis: therapeutic translation for fibrotic disease

2. Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis