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Tissue-engineered autologous grafts for facial bone reconstruction

Published:2016-06-15 Issue:343 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bhumiratana Sarindr¹,Bernhard Jonathan C.¹,Alfi David M.²,Yeager Keith¹,Eton Ryan E.¹,Bova Jonathan³,Shah Forum⁴,Gimble Jeffrey M.⁴⁵,Lopez Mandi J.³,Eisig Sidney B.²,Vunjak-Novakovic Gordana¹

Affiliation:

1. Department of Biomedical Engineering, Columbia University, 500 West 120th Street, New York, NY 10027, USA.

2. Division of Oral and Maxillofacial Surgery, Columbia University College of Dental Medicine, 630 West 168th Street, New York, NY 10032, USA.

3. School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA.

4. LaCell LLC, 1441 Canal Street, New Orleans, LA 70112, USA.

5. Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, 1324 Tulane Avenue, SL-99, New Orleans, LA 70112, USA.

Abstract

Anatomically shaped living bone formed in a portable bioreactor using autologous cells and bone matrix repaired the facial ramus-condyle unit in pigs.

Funder

NIH

New York Partnership Bioaccelerate Program

Mikati Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.

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2. Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone

3. Review:Mesenchymal Stem Cells: Cell–Based Reconstructive Therapy in Orthopedics