Tumor-derived circulating endothelial cell clusters in colorectal cancer

Author:

Cima Igor12,Kong Say Li3,Sengupta Debarka3,Tan Iain B.34,Phyo Wai Min1,Lee Daniel1,Hu Min1,Iliescu Ciprian1,Alexander Irina25,Goh Wei Lin16,Rahmani Mehran3,Suhaimi Nur-Afidah Mohamed1,Vo Jess H.1,Tai Joyce A.3,Tan Joanna H.3,Chua Clarinda4,Ten Rachel4,Lim Wan Jun4,Chew Min Hoe7,Hauser Charlotte A. E.2,van Dam Rob M.8,Lim Wei-Yen8,Prabhakar Shyam3,Lim Bing3,Koh Poh Koon16,Robson Paul39,Ying Jackie Y.1,Hillmer Axel M.3,Tan Min-Han14810

Affiliation:

1. Institute of Bioengineering and Nanotechnology, Singapore 138669, Singapore.

2. Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

3. Genome Institute of Singapore, Singapore 138672, Singapore.

4. National Cancer Centre Singapore, Singapore 169610, Singapore.

5. IFOM-p53Lab Joint Research Laboratory, Singapore 138648, Singapore.

6. Fortis Surgical Hospital, Singapore 289891, Singapore.

7. Singapore General Hospital, Singapore 169608, Singapore.

8. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.

9. The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.

10. Concord Cancer Hospital, Singapore 289891, Singapore.

Abstract

A population of cell clusters circulating in cancer patients consist of tumor-derived endothelial cells reflecting features of the tumor vasculature.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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