Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

Author:

Bonsignori Mattia12ORCID,Kreider Edward F.3ORCID,Fera Daniela4ORCID,Meyerhoff R. Ryan12ORCID,Bradley Todd12ORCID,Wiehe Kevin12ORCID,Alam S. Munir12ORCID,Aussedat Baptiste5ORCID,Walkowicz William E.5ORCID,Hwang Kwan-Ki2ORCID,Saunders Kevin O.26,Zhang Ruijun2ORCID,Gladden Morgan A.2,Monroe Anthony2ORCID,Kumar Amit2,Xia Shi-Mao2,Cooper Melissa2,Louder Mark K.7ORCID,McKee Krisha7,Bailer Robert T.7,Pier Brendan W.4,Jette Claudia A.4,Kelsoe Garnett28ORCID,Williams Wilton B.12ORCID,Morris Lynn9ORCID,Kappes John10,Wagh Kshitij11,Kamanga Gift12,Cohen Myron S.13ORCID,Hraber Peter T.11ORCID,Montefiori David C.26,Trama Ashley2ORCID,Liao Hua-Xin12,Kepler Thomas B.14ORCID,Moody M. Anthony2815ORCID,Gao Feng12ORCID,Danishefsky Samuel J.5,Mascola John R.7ORCID,Shaw George M.3,Hahn Beatrice H.3,Harrison Stephen C.4,Korber Bette T.11ORCID,Haynes Barton F.12ORCID

Affiliation:

1. Department of Medicine, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

2. Duke Human Vaccine Institute, Durham, NC 27710, USA.

3. Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Laboratory of Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

5. Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Department of Surgery, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

7. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

8. Department of Immunology, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

9. National Institute for Communicable Diseases, Johannesburg 2131, South Africa.

10. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

11. Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

12. University of North Carolina Project, Kamuzu Central Hospital, Lilongwe, Malawi.

13. Departments of Medicine, Epidemiology, and Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

14. Department of Microbiology and Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.

15. Department of Pediatrics, Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Identification of maturation stages of V3-glycan neutralizing antibodies explains the long duration required for their development.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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