Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus-Reference-Cited by-全球学者库

Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus

Published:2016-12-14 Issue:369 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wang Qihui¹²,Yang Huabing¹³,Liu Xiaoqing⁴,Dai Lianpan⁵,Ma Tong¹³,Qi Jianxun⁶,Wong Gary²⁶⁷,Peng Ruchao⁶,Liu Sheng⁶⁸,Li Junfu¹,Li Shihua⁶,Song Jian⁶,Liu Jianying⁹,He Jianhua¹⁰,Yuan Hui⁴,Xiong Ying⁴,Liao Yong¹¹,Li Jianhua¹¹,Yang Jianping¹¹,Tong Zhou¹²⁶,Griffin Bryan D.¹²¹³,Bi Yuhai²⁶⁷,Liang Mifang¹⁴,Xu Xiaoning¹⁵,Qin Chuan¹⁶,Cheng Gong⁹,Zhang Xinzheng¹⁷¹⁸,Wang Peiyi¹⁹,Qiu Xiangguo¹²¹³,Kobinger Gary¹²,Shi Yi²⁶,Yan Jinghua¹²³⁶²⁰,Gao George F.²⁵⁶⁷⁸

Affiliation:

1. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

2. Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen 518112, China.

3. School of Life Sciences, Anhui University, Hefei 230039, China.

4. Jiangxi Province Center for Disease Control and Prevention, Nanchang 330029, China.

5. Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.

6. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

7. CAS Center for Influenza Research and Early-warning, Chinese Academy of Sciences, Beijing 100101, China.

8. School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.

9. Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

10. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.

11. Ganzhou Prefecture Center for Disease Control and Prevention, Ganzhou 331000, China.

12. Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

13. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

14. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China.

15. MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, U.K.

16. Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing 100021, China.

17. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

18. Center for Biological Imaging, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

19. Faculty of Biological Science, University of Leeds, Leeds LS2 9JT, U.K.

20. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

Abstract

Zika virus–specific antibodies isolated from a single infected patient show postexposure protection in mice and reveal targets for therapy.

Funder

State Key Research Development Program of China

National Natural Science Foundation of China

NSFC Innovative Research Group

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine