A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure-Reference-Cited by-同舟云学术

A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure

Published:2020-03-04 Issue:533 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cook Sangar Michelle L.¹^ORCID,Girard Emily J.¹^ORCID,Hopping Gene¹^ORCID,Yin Chunfeng¹^ORCID,Pakiam Fiona¹^ORCID,Brusniak Mi-Youn¹^ORCID,Nguyen Elizabeth¹^ORCID,Ruff Raymond¹^ORCID,Gewe Mesfin M.¹²^ORCID,Byrnes-Blake Kelly³^ORCID,Nairn Natalie W.⁴^ORCID,Miller Dennis M.⁴,Mehlin Christopher¹^ORCID,Strand Andrew D.¹^ORCID,Mhyre Andrew J.¹^ORCID,Correnti Colin E.¹^ORCID,Strong Roland K.²^ORCID,Simon Julian A.¹⁵^ORCID,Olson James M.¹^ORCID

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

2. Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

3. Northwest PK Solutions LLC, Sultan, WA 98294, USA.

4. Blaze Bioscience, Seattle, WA 98109, USA.

5. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

A scorpion-derived peptide-steroid conjugate accumulates in cartilage and reverses inflammation in a rat model of arthritis without steroid toxicity.

Funder

Project Violet

Blaze Bioscience Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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