cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy-Reference-Cited by-同舟云学术

cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

Published:2020-06-24 Issue:549 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Li Wenwen¹^ORCID,Lu Lu¹^ORCID,Lu Juanjuan²,Wang Xinran³,Yang Chao²,Jin Jingsi²,Wu Lingling²,Hong Xiaochuan²,Li Fanlin⁴^ORCID,Cao Dongqing²,Yang Yuanqin²,Wu Meng²,Su Bing²,Cheng Jinke⁵^ORCID,Yang Xuanming⁴^ORCID,Di Wen³^ORCID,Deng Liufu¹^ORCID

Affiliation:

1. Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital and Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

2. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

3. Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

4. Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.

5. Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Abstract

Cell-intrinsic cGAS-STING–mediated DNA sensing promotes the formation of stem cell–like CD8 + T cells for effective cancer T cell therapy.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Shanghai Municipal Commission of Health and Family Planning

Shanghai Municipal Health Commission

Innovative research team of high-level local universities in Shanghai

National Thousand Youth Talents Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject